Multisystem inflammatory syndrome in children — what parents need to know?

Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare but serious condition that can occur in children after a COVID-19 infection. It causes inflammation in multiple organs, including the heart, lungs, kidneys, brain, skin, eyes, and gastrointestinal tract.
Symptoms of MIS-C
MIS-C symptoms can vary but may include:

  • High fever (lasting more than 24 hours)
    Abdominal pain, diarrhea, or vomiting
  • Red or swollen eyes Weakness or fatigue
  • Swelling of hands or feet
  • Red or cracked lips, swollen tongue (similar to
  • Kawasaki disease)
  • Fast heart rate or difficulty breathing


What Causes MIS-C?
MIS-C is believed to be an excessive immune response triggered by a previous COVID-19 infection, even if the child had mild or no symptoms of COVID-19.
When to Seek Medical Help
Go to the emergency room immediately if your child has:


Difficulty breathing

  • Chest pain or pressure that doesn’t go away
  • Confusion or difficulty staying awake
  • Bluish lips or face
    severe pain in the abdomen

Treatment for MIS-C

  • Doctors typically use a combination of treatments, including:
  • Anti-inflammatory medications (such as steroids or IV immunoglobulin)
  • Fever reducers and pain relievers
  • IV fluids to keep you hydrated Oxygen support if needed


Can MIS-C Be Prevented?
The best way to lower the risk of MIS-C is to prevent COVID-19 infections by:

  • Ensuring children are vaccinated if eligible
  • Encouraging handwashing and hygiene
  • Avoiding close contact with sick individuals


Symptoms of MIS-C
Multisystem Inflammatory Syndrome in Children (MIS-C) can affect multiple organs. Symptoms may include:

  • Fever (lasting more than 24 hours)
  • Gastrointestinal issues – Abdominal pain, diarrhea, vomiting
  • Skin and mucous membrane changes –
  • Rash, red or cracked lips, swollen tongue (like “strawberry tongue”)
  • Eye inflammation –
  • Redness in the eyes (conjunctivitis)
  • Swelling – Hands, feet, or lymph nodes
  • Heart and circulation issues – Rapid heartbeat, low blood pressure, chest pain
  • Breathing problems –
  • Shortness of breath, rapid breathing
  • Neurological symptoms – Headache, dizziness, confusion, fatigue

Treatment for MIS-C
There is no specific cure, but doctors treat MIS-C by managing inflammation and symptoms. Treatment consists of:

Hospital care – Most children need hospitalization, and some may require ICU care.
Anti-inflammatory medications – IV immunoglobulin (IVIG) and corticosteroids to reduce immune system overreaction.
Fever and pain control – Acetaminophen or ibuprofen.
IV fluids – To prevent dehydration.
Oxygen support – If there are breathing difficulties.
Heart medications – If there are heart complications.

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